Methods and compositions for inducing hematopoietic cell differentiation
US10858628B2 · kind B2 · utility
12Cited by
34References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 26, 2016 |
| Grant date | Dec 8, 2020 |
| Priority date | — |
| Expiry date | Apr 30, 2037 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides culture platforms, cell media, and methods of differentiating pluripotent cells into hematopoietic cells. The invention further provides pluripotent stem cell-derived hematopoietic cells generated using the culture platforms and methods disclosed herein, which enable feed-free, monolayer culturing and in the absence of EB formation. Specifically, pluripotent stem cell-derived hematopoietic cell of this invention include, and not limited to, iHSC, definitive hemogenic endothelium, hematopoietic multipotent progenitors, T cell progenitors, NK cell progenitors, T cells, NK cells, NKT cells and B cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.