Polymeric bile acid nanocompositions targeting the pancreas and colon
US10864170B2 · kind B2 · utility
1Cited by
16References
25Claims
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Key dates
| Filing date | Sep 2, 2016 |
| Grant date | Dec 15, 2020 |
| Priority date | — |
| Expiry date | Sep 2, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical composition containing poly(bile) acid (PBA) polymers for oral delivery of agent(s) show enhanced uptake by the pancreas, liver, and colon. These nanoparticles show significant retention in the pancreas and colon and are therefore useful for selective delivery. The examples demonstrate efficacy of oral administration of insulin to treat diabetes, and oral induction of tolerance by administration of insulin or ovalbumin in combination with rapamycin. Diabetic animals treated with the insulin or insulin with rapamycin showed normalization of blood glucose levels.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.