Stable formulations for immune-modulatory macrolides

US10864200B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Ewelina Hegel · Mannheim, DE
• Hans-Peter Josel · Weilheim, DE
• Eloisa Lopez-Calle · Ludwigshafen, DE
• Josef Roedl · Mutterstadt, DE
• Noah Weiss · Munich, DE
• Benjamin Tiemann · Munich, DE

Key dates

• Filing date: Sep 6, 2019
• Grant date: Dec 15, 2020
• Expiry date: Sep 6, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present description relates to a liquid composition having at least one immune-modulatory macrolide compound and an essentially cell-free blood hemolysate. The present description further relates to a method for manufacturing a stabilized immune-modulatory macrolide calibration solution, by a) preparing a solution comprising an essentially cell-free blood hemolysate, b) admixing a predetermined amount of at least one immune-modulatory macrolide into said solution comprising an essentially cell-free blood hemolysate, and, thereby c) manufacturing a stabilized immune-modulatory macrolide calibration solution. Furthermore, the present description relates to kits, uses, devices, methods and to an immune-modulatory macrolide compound calibration solution related thereto.