Ligands selective to alpha 6 subunit-containing GABAA receptors and their methods of use

US10865203B2 · kind B2 · utility

Assignees

• UWM Research Foundation, Inc. · US
• MEDICAL UNIVERISITY OF VIENNA · AT

Inventors

• James M. Cook · Milwaukee, US
• Daniel Knutson · Elkhorn, US
• Marko Mihovilovic · Perchtoldsdorf, AT
• Laurin Wimmer · Gmunden, AT

Key dates

• Filing date: Jun 3, 2016
• Grant date: Dec 15, 2020
• Expiry date: Jun 3, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are novel pyrazolo-quinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.