NKG2D-IG fusion protein for cancer immunotherapy
US10865232B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Nov 11, 2016 |
| Grant date | Dec 15, 2020 |
| Priority date | — |
| Expiry date | Apr 10, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for cancer immunotherapy are provided. The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising a dimeric NKG2D portion and an Fc portion, which binds one or more NKG2D ligands. In some embodiments, the molecule further comprises a drug moiety (e.g., an IL15/Ra moiety). The methods disclosed herein are useful for the treatment of cancer that is associated with abnormal expression of one or more NKG2D ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.