Multi-lineage hematopoietic precursor cell production by genetic programming
US10865381B2 · kind B2 · utility
1Cited by
5References
35Claims
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Key dates
| Filing date | Oct 20, 2016 |
| Grant date | Dec 15, 2020 |
| Priority date | — |
| Expiry date | Oct 20, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure generally regards methods and compositions for providing multi-lineage hematopoietic precursor cells from pluripotent stem cells (PSCs). The PSCs comprise an expression construct encoding an ETS/ERG gene, GATA2 and HOXA9. Also provided are methods for providing hematopoietic stem cells capable of long-term engraftment in mammals, such as humans. Further provided are therapeutic compositions including the provided hematopoietic stem cells and precursors of hematopoietic cells, and methods of using such for the treatment of subjects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.