Methods for tagging DNA-encoded libraries
US10865409B2 · kind B2 · utility
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109References
18Claims
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Key dates
| Filing date | Sep 7, 2012 |
| Grant date | Dec 15, 2020 |
| Priority date | — |
| Expiry date | Nov 3, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/11
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.