Chimeric protein

US10869911B2 · kind B2 · utility

Assignee

• AUTOLUS LIMITED · GB

Inventors

• Martin Pulé · London, GB
• Brian Philip · London, GB

Key dates

• Filing date: Apr 12, 2016
• Grant date: Dec 22, 2020
• Expiry date: Jun 30, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/03
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a chimeric protein which comprises a multi-spanning transmembrane protein fused to a FAS endodomain, wherein the multi-spanning transmembrane protein binds an extracellular ligand, leading to activation of the FAS endodomain. The chimeric protein is useful as a suicide gene. The invention also provides a cell, such as a T cell comprising such a chimeric protein, which is useful in adoptive T cell immunotherapy approaches.