Zwitterionic propargyl-linked antifolates useful for treating bacterial infections

US10870625B2 · kind B2 · utility

Assignee

• UNIVERSITY OF CONNECTICUT · US

Inventors

• Dennis L. Wright · Farmington, US
• Amy C. Anderson
• Eric William Scocchera · Mansfield Center, US
• Narendran Gummudipundi Dayanandan · Mansfield Center, US
• Santosh Kumar Keshipeddy · Hamden, US
• Stephanie Reeve · Manchester, US
• Michael N. Lombardo · Manchester, US
• Michael Henry Cynamon · Town of DeWitt, US

Key dates

• Filing date: Jan 9, 2017
• Grant date: Dec 22, 2020
• Expiry date: Jan 9, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides compounds of the formula I and the pharmaceutically acceptable salts thereof. The variables, e.g. R1, R2, R3, R4, A, B, J, V, W, M, J and Ar are defined herein. The disclosure also provides pharmaceutical compositions comprising a compound or salt of formula I and a pharmaceutically acceptable carrier, methods of inhibiting dihydrofolate reductase (DHFR) in vitro or in vivo with a compound or salt of formula I, and methods of treating a bacterial infections, fungal infections, and protozoal infections with a compound or salt of formula I. A compound or salt of formula I can be the first and only active ingredient used in a pharmaceutical composition or method of this disclosure or may be combined with one or more additional active ingredients that are not compounds or salts of formula I.