Patent · US Active

Salt of quinazoline derivative, preparation method therefor and application thereof

US10870627B2 · kind B2 · utility

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12Claims

0Family size

Assignee

Shanghai Pharmaceuticals Holding Co., Ltd. · CN

Inventors

Guangxin Xia · Shanghai, CN
Di Li · Lanzhou, CN
Ning Zhou · Vadnais Heights, US
Ao Chen · Lo Wu, CN
Liang Zhao · Dalian, CN
Jiansheng Han · Shanghai, CN
Yanjun Liu · Shanghai, CN

Key dates

Filing date	Sep 22, 2017
Grant date	Dec 22, 2020
Priority date	—
Expiry date	Sep 22, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoroanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.