Bifunctional cytotoxic agents containing the CTI pharmacophore
US10870706B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Mar 15, 2016 |
| Grant date | Dec 22, 2020 |
| Priority date | — |
| Expiry date | Apr 29, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/05
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to novel bifunctional CTI-CTI and CBI-CTI dimers of the formula: F1-L1-T-L2-F2 where F1, L1, T, L2 and F2 are as defined herein, useful for the treatment for proliferative diseases, where the inventive dimers can function as stand-alone drugs, payloads in antibody-drug-conjugates (ADCs), and linker-payload compounds useful in connection with the production or administration of such ADCs; and to compositions including the aforementioned dimers, linker-payloads and ADCs, and methods for using these dimers, linker-payloads and ADCs, to treat pathological conditions including cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.