Specific murine and humanized monoclonal antibodies detecting pathology associated secondary structure changes in proteins and peptides
US10870709B2 · kind B2 · utility
0Cited by
2References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 22, 2017 |
| Grant date | Dec 22, 2020 |
| Priority date | — |
| Expiry date | Jul 22, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to antibodies and binding fragments thereof that bind the β-sheet secondary structure of a pathological monomeric or oligomeric non-fibrillar proteins without binding to the non-toxic, non-pathological forms of these proteins or peptides These antibodies and binding fragments thereof are suitable for the diagnosis, prevention, and treatment of protein conformational disorders including all amyloid diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.