Patent · US Active

Fusion proteins comprising enzyme replacement therapy enzymes

US10870837B2 · kind B2 · utility

9Cited by

59References

47Claims

0Family size

Assignee

DENALI THERAPEUTICS INC. · US

Inventors

Anastasia Henry · South San Francisco, US
Mihalis Kariolis · South San Francisco, US
Cathal S. Mahon · San Francisco, US
Adam P. Silverman · South San Francisco, US
Ankita Srivastava · Mumbai, IN

Key dates

Filing date	Mar 15, 2019
Grant date	Dec 22, 2020
Priority date	—
Expiry date	Mar 15, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y310/01001
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.