Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics
US10871440B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Apr 25, 2019 |
| Grant date | Dec 22, 2020 |
| Priority date | — |
| Expiry date | Apr 25, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/1493
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided are methods and devices for assessing biological particles for use in cell immunotherapy. By utilizing a microfluidic chip device together with optical force measurement and cell imaging, the methods enable comprehensive assessment and characterization of biological particles with regard to morphology, motility, binding affinities, and susceptibility to external forces, including but not limited to, chemical, biochemical, biological, physical and temperature influences. The methods enable the selection and production of biological particles, such as engineered T-cells, for use in immunotherapy and biomanufacturing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.