Application of substituted cinnamamide derivatives in preparation of anti-anxiety medication

US10874636B2 · kind B2 · utility

Assignee

• TASLY PHARMACEUTICAL GROUP CO., LTD. · CN

Inventors

• Min Han · Tianjin, CN
• Xiaohui Ma · Tianjin, CN
• Wangyi Zhou · Tianjin, CN
• Yanyong Liu · Zhuhai, CN
• Yanchuan Li · Tianjin, CN
• Jing Wang · Beijing, CN
• Shuiping Zhou · Tianjin, CN
• He Sun · Shanghai, CN
• Yonghong Zhu · Tianjin, CN

Key dates

• Filing date: Jan 20, 2017
• Grant date: Dec 29, 2020
• Expiry date: Jan 20, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is an application of substituted cinnamamide derivatives in the preparation of anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, R1 is —H, —OH, —F, —Cl, —Br, —I, —OCH3, —OCF3, —OCHF2, —OCH2F, —CF3, —CHF2, —CH2F, —CH3, —CH3CH2, —CF3CH2, —CN, —NO2, —NH2 or —COOR5; R2 is H, C1-C10 linear alkyl, C3-C10 branched alkyl, C3-C10 cyclic alkyl, C1-C10 hydroxyalkyl or a N-substituted piperazine-derived group; or R2 is a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group.