Method of providing patient specific immune response in amyloidoses and protein aggregation disorders

US10874725B2 · kind B2 · utility

Assignee

• NEW YORK UNIVERSITY · US

Inventors

• Karsten Henco · Erkrath, DE
• Roger Nitsch · Zumikon, CH
• Jan Grimm · Stintenberger Straße, CH
• Anja Zeller · Bellinzona, CH
• Marcel Maier · Zürich, CH

Key dates

• Filing date: Dec 18, 2017
• Grant date: Dec 29, 2020
• Expiry date: Dec 18, 2037

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.