Patent · US Active

Tumor vascular marker-targeted vaccines

US10874728B2 · kind B2 · utility

0Cited by

0References

3Claims

0Family size

Assignee

The Trustees of the University of Pennsylvania · US

Inventors

George Coukos · Lansdowne, US
Andrea Facciabene · Philadelphia, US

Key dates

Filing date	Mar 21, 2016
Grant date	Dec 29, 2020
Priority date	—
Expiry date	Mar 21, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides methods of immunizing a subject against a tumor, inhibiting tumor growth, inhibiting tumor recurrence, treating, suppressing the growth of, or decreasing the incidence of a tumor, overcoming tolerance to a tumor vasculature marker (TVM) in a subject comprising the step of administering a vaccine comprising a TVM or a nucleic acid encoding a TVM and related vaccines. The present invention also provides a method of targeting a tumor vasculature in a subject having a tumor comprising the step of contacting said subject with a labeled compound that binds a) a tumor vasculature marker (TVM) or b) a nucleic acid molecule encoding said TVM.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.