Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B

US10875876B2 · kind B2 · utility

Assignee

• Janssen Sciences Ireland UC · IE

Inventors

• Sandrine Marie Helene Vendeville · Woluwe-Saint-Pierre - Sint-Pieters-Woluwe, BE
• Stefaan Julien Last · Lint, BE
• Samuël Dominique Demin · Ekeren, BE
• Sandrine Céline GROSSE · Turnhout, BE
• Geerwin Yvonne Paul Haché · Brasschaat, BE
• Lili Hu · Mechelen, BE
• Serge Maria Aloysius Pieters · Wichelen, BE
• Geert Rombouts · Borsbeek, BE
• Koen Vandyck · Beringen, BE
• Wim Gaston Verschueren · Berchem, BE
• Pierre Jean-Marie Bernard Raboisson · Sligo, IE

Key dates

• Filing date: Jun 28, 2016
• Grant date: Dec 29, 2020
• Expiry date: Jun 28, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D515/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of HBV replication of Formula (I-A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.