Antibodies and molecules that immunospecifically bind to BTN1A1 and the therapeutic uses thereof

US10875920B2 · kind B2 · utility

Assignees

• STCUBE & CO., INC. · KR
• The Board of Regents of the University of Texas System · US

Inventors

• Stephen Sunghan Yoo · Centreville, US
• Michael Joseph Surace · Germantown, US
• Steven Lin · Palo Alto, US
• Amrish Sharma · Houston, US

Key dates

• Filing date: Dec 1, 2016
• Grant date: Dec 29, 2020
• Expiry date: Jan 7, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are molecules having an antigen binding fragment that immunospecifically binds to BTN1A1, such as anti-BTN1A1 antibodies. These molecules include those having an antigen binding fragment that immunospecifically binds to glycosylated BTN1A1, such as anti-glycosylated BTN1A1 antibodies. Methods of making and using these molecules are also provided, including methods of using them in cancer therapies, or as cancer diagnostics.