Cell culture medium for enhanced hepatocyte function
US10876096B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Nov 25, 2013 |
| Grant date | Dec 29, 2020 |
| Priority date | — |
| Expiry date | Nov 25, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/90245
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Cell culture compositions containing LFM-A13 or a structurally related compound can enhance global hepatic function. For example, LFM-A13 is shown to enhance levels of a broad variety of drug metabolism enzymes, including CYP enzymes, and other hepatic enzymes. LFM-A13 is also shown to promote differentiation of stem cells into hepatocytes. LFM-A13 and structurally related compounds can be used in cell culture to enhance global drug metabolism of liver cells for enhanced in vitro study the effects of drug metabolism on other candidate drug compounds.
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