Method of producing 2′-fucosyllactose using recombinant Corynebacterium glutamicum
US10876122B2 · kind B2 · utility
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Key dates
| Filing date | Oct 1, 2019 |
| Grant date | Dec 29, 2020 |
| Priority date | — |
| Expiry date | Oct 1, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y402/01047
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided is a method of producing 2′-fucosyllactose including culturing in a medium supplemented with lactose a recombinant Corynebacterium glutamicum transformed to express α-1,2-fucosyltransferase, transformed to express GDP-D-mannose-4,6-dehydratase, transformed to express GDP-L-fucose synthase, and transformed to express lactose permease, wherein the recombinant Corynebacterium glutamicum has phosphomannomutase and GTP-mannose-1-phosphate guanylyltransferase.
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