Adeno-associated virus polynucleotides, polypeptides and virions

US10882886B2 · kind B2 · utility

Assignees

• Children's Medical Research Institute · CA
• THE SYDNEY CHILDREN'S HOSPITALS NETWORK (RANDWICK AND WESTMEAD (INCORPORATING THE ROYAL ALEXANDRA HOSPITAL FOR CHILDREN) · AU
• THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (WASHINGTON DC) · US

Inventors

• Claus Hallwirth · Parramatta, AU
• Ian Alexander · Brier, US
• Richard S. Smith · Mendota Heights, US
• Robert Kotin · Bethesda, US

Key dates

• Filing date: May 3, 2017
• Grant date: Jan 5, 2021
• Expiry date: May 3, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2750/14152
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polypeptides are encoded by an adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely-related marsupial species. Nucleic acid molecules encode the polypeptides. Vectors can include the nucleic acid molecules, and recombinant AAV virions can include the polypeptides. A chimeric capsid protein can also include an MAAV-EVE1 polypeptide.