Patent · US Active

Method of separating Factor VIII from blood products

US10889630B2 · kind B2 · utility

0Cited by

0References

17Claims

0Family size

Assignee

OCTAPHARMA AG · CH

Inventors

Stefan Winge · Kramfors, SE
Per Rosén · Lund, SE
Alex Scheepers · Sollentuna, SE

Key dates

Filing date	Feb 10, 2017
Grant date	Jan 12, 2021
Priority date	—
Expiry date	Apr 29, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/55
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

The invention provides a method for separating a Factor VIII (FVIII) protein from a first composition comprising the FVIII protein, which contains at least the light chain of FVIII, and a von-Willebrand-Factor (vWF) protein which comprises at least the FVIII binding domain of vWF, wherein the FVIII protein can form a complex with the vWF protein, the method comprising the steps: contacting the first composition with an affinity resin comprising a ligand and a matrix, wherein the ligand has an affinity to the light chain of FVIII, and separating the affinity resin from the mixture to obtain a modified first composition and a second composition, wherein the second composition contains the affinity resin, and a complex of the FVIII protein and the vWF protein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.