Methods and compositions for enhancing targeted transgene integration
US10889834B2 · kind B2 · utility
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Key dates
| Filing date | Dec 14, 2015 |
| Grant date | Jan 12, 2021 |
| Priority date | — |
| Expiry date | Feb 15, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are methods and compositions for enhancing insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease or a hemophilia by administering one or more topoisomerases inhibitors, one or more stabilizers of R loop formation or inhibitors of R-loop repair and/or one or more up-regulators of the TC-NER pathway to the target cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.