Polypeptide ligands specific for plasma kallikrein
US10894808B2 · kind B2 · utility
7Cited by
1References
42Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 3, 2019 |
| Grant date | Jan 19, 2021 |
| Priority date | — |
| Expiry date | Jan 3, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are specific for the human and rat protease plasma kallikrein and are modified in one or two peptide loops to enhance potency and/or protease resistance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.