Patent · US Active

Growth differentiation factor 15 (GDF-15) constructs

US10894814B2 · kind B2 · utility

3Cited by

17References

25Claims

0Family size

Assignee

AMGEN INC. · US

Inventors

Yumei Xiong · Palo Alto, US
Yi Zhang · Nanjing, CN
Jackie Z. Sheng · Thousand Oaks, US
Agnes Eva Hamburger · Newbury Park, US
Murielle Veniant-Ellison · Thousand Oaks, US
Grant Shimamoto · Newbury Park, US
Xiaoshan MIN · Burlingame, US
Zhulun Wang · Palo Alto, US
Jie Tang · Singapore, SG
Gunasekaran Kannan · Daly City, US
Marissa MOCK · Newbury Park, US
Kenneth W. Walker · Newbury Park, US

Key dates

Filing date	Nov 29, 2017
Grant date	Jan 19, 2021
Priority date	—
Expiry date	Nov 29, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/31
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.