Dihydroetorphine for the provision of pain relief and anaesthesia

US10898479B2 · kind B2 · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• John Walker Watkins · Cambridge, GB
• Alexander Oksche · Limburg, DE
• Kevin John Smith · Cambridge, GB
• Heikki Mansikka · Cambridge, GB
• Paul Robert Bailey · Auckland, NZ

Key dates

• Filing date: May 30, 2014
• Grant date: Jan 26, 2021
• Expiry date: Oct 9, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D489/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a method of providing pain relief in a human subject in need thereof comprising administering (R)-dihydroetorphine to said subject, wherein said (R)-dihydroetorphine is administered in a dose of at least 0.01 μg/kg, preferably at least 0.05 μg/kg, and the level of respiratory depression in said subject is 65 or less % relative to the baseline level pre-administration of (R)-dihydroetorphine.