Benzylamino substituted quinazolines and derivatives as SOS1 inhibitors

US10898487B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Dirk Kessler · Wien, AT
• Christiane Kofink · Perchtoldsdorf, AT
• Matthew Russell Netherton · Danbury, US
• Juergen Ramharter · Wien, AT
• Tobias Wunberg · Mödling, AT

Key dates

• Filing date: Dec 21, 2017
• Grant date: Jan 26, 2021
• Expiry date: Dec 21, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention encompasses compounds of formula (I), wherein the groups R1 to R7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.