Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein

US10898589B2 · kind B2 · utility

Assignee

• CureVac AG · DE

Inventors

• Andreas Thess · Aspenhausiedlung, DE
• Thomas SCHLAKE · Gundelfingen, DE
• Jochen Probst · Wolfschlugen, DE

Key dates

• Filing date: Feb 19, 2018
• Grant date: Jan 26, 2021
• Expiry date: Mar 14, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2840/105
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure concerns a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a therapeutic protein or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. The present disclosure further concerns a method for increasing the expression of a peptide or protein comprising a therapeutic protein or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.