3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof
US10899741B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 13, 2017 |
| Grant date | Jan 26, 2021 |
| Priority date | — |
| Expiry date | Nov 13, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a 3,4-bipyridyl pyrazole derivative, and a preparation method therefor and a medical application thereof. Specifically, the present invention relates to a new 3,4-bipyridyl pyrazole derivative as shown in formula (I), a preparation method for the derivative, a pharmaceutical composition containing the derivative, a use of the derivative as a therapeutic agent, in particular as a TGF-β inhibitor, and a use of the derivative in the preparation of a drug which treats, prevents or reduces cancer mediated by TGF-β overexpression. The substituents in formula (I) have the same definitions as in the description.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.