Production of soluble HIV envelope trimers in planta
US10899801B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Oct 13, 2017 |
| Grant date | Jan 26, 2021 |
| Priority date | — |
| Expiry date | Oct 13, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16134
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a method for producing a recombinant HIV glycoprotein polypeptide in a plant and to trimeric complexes of the recombinant, plant-produced HIV glycoprotein polypeptide which mimic the native HIV Env complex. The invention also relates to nucleic acids encoding the recombinant polypeptides, expression vectors containing the aforementioned nucleic acids and to pharmaceutical compositions, uses and methods of eliciting an immune response against HIV in a subject using the recombinant polypeptides and trimeric complexes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.