Methods of reducing or preventing intimal damage caused by mechanical stimulation of endothelial cells
US10900040B2 · kind B2 · utility
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Key dates
| Filing date | May 25, 2016 |
| Grant date | Jan 26, 2021 |
| Priority date | — |
| Expiry date | Jul 5, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/315
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Embodiments of the disclosure encompass methods and/or compositions for ameliorating or preventing intimal damage caused by mechanical stimulation of endothelial cells. The damage may be caused by use of a device within an artery, vein, or capillary of an individual, such as to remove a thrombus, an embolus or an atherosclerotic plaque in the vessel. Treatment and prevention embodiments concern therapeutically effective amounts of one or more antagonists of the SUR1-TRPM4 channel that is upregulated upon the mechanical stimulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.