Induced pacemaker and Purkinje cells from adult stem cells
US10905722B2 · kind B2 · utility
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Key dates
| Filing date | Mar 7, 2018 |
| Grant date | Feb 2, 2021 |
| Priority date | — |
| Expiry date | Mar 7, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
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