Patent · US Active

Compositions and methods for enhancing cancer radiotherapy

US10905723B2 · kind B2 · utility

4Cited by
13References
9Claims
0Family size

Inventor

Key dates

Filing dateJun 13, 2018
Grant dateFeb 2, 2021
Priority date—
Expiry dateJun 13, 2038

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61N5/10
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A nutritional supplement containing fish oil and selenium has been identified that potentiates radiotherapy of tumors in a synergistic fashion. Cotherapy with such a supplement and radiotherapy results in substantially improved reductions in tumor volume of animal models relative to radiotherapy alone, and reduces common side effects such as weight loss, inflammation, and damage to the gastrointestinal tract. Such cotherapy was also found to reduce the incidence of metastasis from the primary implantation site, and to modulate expression of genes associated with apoptosis in tumor cells. A formulation for such a supplement that is both well tolerated and palatable is also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.