Patent · US Active

Chemosynthetic cyclo-hepta modified peptide capable of inhibiting toxin of Staphylococcus aureus and use thereof

US10905735B2 · kind B2 · utility

0Cited by

0References

9Claims

0Family size

Assignee

ZHONGCHENG INVESTMENT MANAGEMENT (SHANGHAI) CO., LTD · CN

Inventors

Ningsheng Shao · Beijing, CN
Guang Yang · Nanhu, CN
Liangyou Wang · Suzhou, CN
Hongmei DING · Beijing, CN
Yaping GAO · Beijing, CN
Shaohua Li · Beijing, CN
Hui Li · Carlsbad, US
Jie Li · Shanghai, CN
Jie Dong · Beijing, CN
Wenhui Xia · Haikou, CN
Xiaoping Liang · Collegeville, US

Key dates

Filing date	Apr 27, 2017
Grant date	Feb 2, 2021
Priority date	—
Expiry date	Apr 27, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K7/08
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a chemosynthetic cyclo-hepta modified peptide capable of inhibiting toxins of Staphylococcus aureus and a use thereof. The chemosynthetic peptide can specifically inhibit production of the toxins of Staphylococcus aureus by means of the binding of the RNAIII activator protein by a Staphylococcus aureus autocrine. The invention also relates to the use of the chemosynthetic peptide in the pharmaceutical field. The sequence general formula of the chemosynthetic cyclo-hepta modified peptide is CH3—(CH2)m-X-G-(CQHWWHWYC)—(R)n-Y. The results show that the modified peptide can be dissolved well in water and has good activity against the toxins of Staphylococcus aureus.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.