Compositions and methods for activating “stimulator of interferon gene”-dependent signalling
US10906930B2 · kind B2 · utility
2Cited by
9References
12Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Oct 28, 2016 |
| Grant date | Feb 2, 2021 |
| Priority date | — |
| Expiry date | Oct 28, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/572
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′- or 3′-mono-fluoro substituted, or 2′3′-di-fluoro substituted mixed linkage 2′,5′-3′,5′ CDNs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.