Modified alpha hemolysin polypeptides and methods of use
US10906945B2 · kind B2 · utility
1Cited by
8References
18Claims
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Key dates
| Filing date | Jul 12, 2018 |
| Grant date | Feb 2, 2021 |
| Priority date | — |
| Expiry date | Jul 12, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/143333
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are alpha hemolysin polypeptides comprising modified amino acid sequences that can reduce the rate of translocation of a polymer. Also provided herein are apparatuses and devices comprising modified hemolysin polypeptides. Also provided herein are methods of using modified alpha hemolysin proteins for use in characterizing and/or sequencing a polymer or for use as molecular sensors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.