Immunomodulatory fusion proteins
US10906957B2 · kind B2 · utility
2Cited by
8References
8Claims
0Family size
Assignee
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Key dates
| Filing date | Sep 27, 2017 |
| Grant date | Feb 2, 2021 |
| Priority date | — |
| Expiry date | Sep 27, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10371
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a fusion protein, e.g., a cytokine receptor fusion protein, e.g., a TGFβ trap, with a novel linker sequence to permit the fusion protein to functionally optimally, e.g., to permit a cytokine receptor portion of a cytokine receptor fusion protein to bind optimally to its target cytokine. The fusion proteins, or expression vectors encoding for the fusion proteins, e.g., oncolytic adenoviral expression vectors, can be used to treat cell proliferative diseases and disorders, including certain forms of cancer and inflammatory disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.