Methods and compositions involving RAD51 inhibitors
US10912761B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Nov 27, 2013 |
| Grant date | Feb 9, 2021 |
| Priority date | — |
| Expiry date | Dec 15, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/456
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.