Topical formulations based on ionic species for skin treatment

US10912834B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Michael Zakrewsky · Lompoc, US
• Samir Mitragotri · Goleta, US

Key dates

• Filing date: Aug 29, 2017
• Grant date: Feb 9, 2021
• Expiry date: Oct 11, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61Q19/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions containing a complex that contains a cation with alkyl chains and a macromolecule anion, and methods of making and using are disclosed. The compositions are typically charge neutral and a liquid at room temperature and standard pressure. The macromolecule anions may be nucleic acids, peptides, proteins, and/or carbohydrates. The compositions have enhanced penetration across the skin barrier (stratum corneum) and into the skin cells, delivering the macromolecules to the skin cells. The compositions are topically applied to the skin and are particularly useful for treatment of skin conditions.