Degradable thiol-ene polymers and methods of making thereof

US10912837B2 · kind B2 · utility

Assignee

• MOSAIC BIOSCIENCES, INC. · US

Inventors

• Alexei KAZANTSEV · Erie, US
• Peter D. MARINER · Superior, US
• Martin Stanton · Stow, US

Key dates

• Filing date: Feb 9, 2016
• Grant date: Feb 9, 2021
• Expiry date: May 7, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2389/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.