RAGE fusion proteins with improved stability and ligand binding affinity and uses thereof
US10913784B2 · kind B2 · utility
0Cited by
4References
15Claims
0Family size
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Key dates
| Filing date | Sep 13, 2019 |
| Grant date | Feb 9, 2021 |
| Priority date | — |
| Expiry date | Sep 13, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides soluble RAGE-Fc fusion proteins with increased stability and extended half-life capable of binding endogenous RAGE ligands with high apparent affinity. The present invention also provides methods of making and using stable, soluble RAGE-Fc fusion proteins. These soluble RAGE-Fc fusion proteins are useful as therapeutics based on their ability to bind endogenous RAGE ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.