Patent · US Active

Modulators of ROR1-ROR2 binding

US10913798B2 · kind B2 · utility

1Cited by

0References

14Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Thomas J. Kipps · San Diego, US
Jian Yu · New Providence, US

Key dates

Filing date	Apr 25, 2016
Grant date	Feb 9, 2021
Priority date	—
Expiry date	Sep 30, 2036

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/02
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Provided herein are, inter alia, methods of identifying agents that are capable inhibiting the binding (e.g., coupling) between a ROR1 protein and a ROR2 protein. By interfering with ROR1-ROR2 coupling (binding) the agents identified using the methods provided herein inhibit non-canonical Wnt5a signaling. Thus, the agents identified by the methods provided herein may, inter alia, be useful for cancer diagnosis and therapy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.