Method for quantitative detection of blood lipid content in blood based on terahertz spectroscopy

US10914678B2 · kind B2 · utility

Assignee

• University of Shanghai for Science and Technology · CN

Inventors

• Yan Peng · Shanghai, CN
• Yiming Zhu · Hefei, CN
• Liping Wang · Huaibei, CN
• Qingrou Yang · Shanghai, CN
• Jiayu Zhao · Shanghai, CN
• Zhijia Liu · Shanghai, CN
• Yang Liu · Iowa City, US
• Xinyu Tang · Chengdu, CN
• Keying LIU · Shanghai, CN
• Lin Guo · Saratoga, US
• Songlin Zhuang · Shanghai, CN

Key dates

• Filing date: Mar 13, 2019
• Grant date: Feb 9, 2021
• Expiry date: Aug 14, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2001/4088
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for quantitative detection of blood lipid in blood based on terahertz spectroscopy, including: matching the terahertz spectral absorption coefficient curves of blood samples obtained in step 3 with parameters of component concentration and component type of the blood lipid detected by hospital instruments, and establishing a terahertz blood lipid parameter database by combining the time-domain signal data of samples of the triglyceride and cholesterol; determining parameters of a support vector regression (SVR) model; performing a training with the training set as input to the SVR model to obtain a support vector and a corresponding weight; and testing the test set of an unknown blood sample using the trained support vector and the corresponding weight.