Substituted pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones for cancer treatment

US10918735B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Board of Trustees of the University of Illinois · US

Inventors

• Mohammad Movassaghi · Lincoln, US
• Justin Kim · Burbank, US
• Paul J. Hergenrother · Champaign, US
• Karen Morrison · Champaign, US
• Nicolas Cedric Boyer · Somerville, US

Key dates

• Filing date: Mar 5, 2019
• Grant date: Feb 16, 2021
• Expiry date: Mar 5, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The synthesis of various pyrazino[1′,2′:1,5]pyrrolo[2,3-B]-indole-1,4-dione analogs has been successfully implemented in the present application. From these efforts, compounds having the structure of Formula I-a or Formula I-b: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, are provided herein. These biologically active derivatives have been used to effectively treat various diseases including cancer.