Patent · US Active

Process for the preparation of crystalline form C of avibactam sodium

US10919893B2 · kind B2 · utility

0Cited by

1References

15Claims

0Family size

Assignee

Sandoz AG · CH

Inventors

Michael Fischer · Ludwigshafen, DE
Veronika Werner · Brixlegg, AT
Andreas Lechner · Kundl, AT
Brigitte Staggl · Kundl, AT

Key dates

Filing date	Feb 7, 2018
Grant date	Feb 16, 2021
Priority date	—
Expiry date	Feb 7, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a process for the preparation of avibactam sodium in polymorphic form C comprising the steps (i) providing a mixture comprising avibactam or a salt thereof and a solvent, wherein the mixture has a water content of less than 2% by weight based on the weight of the mixture; (ii) increasing the temperature of the mixture provided in (i) to at least 55° C. and providing a positive pressure; adding a sodium source to the mixture in step (i) and/or (ii) if the form of avibactam provided in (i) is not avibactam sodium; thereby obtaining avibactam sodium in polymorphic form C.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.