Hetero-halo inhibitors of histone deacetylase

US10919902B2 · kind B2 · utility

Assignee

• Alkermes, Inc. · US

Inventors

• Martin R. Jefson · Stonington, US
• John A. Lowe, III · Stonington, US
• Fabian Dey · Basel, CH
• Andreas Bergmann · Berlin, DE
• Andreas Schoop · Overath, DE
• Nathan Oliver Fuller · Arlington, US

Key dates

• Filing date: Dec 26, 2019
• Grant date: Feb 16, 2021
• Expiry date: Dec 26, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.