P-chiral phosphine ligands and use thereof for asymmetric synthesis

US10919921B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Armin Boerner · Rostock, DE
• Jens Holz · Kessin, DE
• Katharina Rumpel · Rostock, DE

Key dates

• Filing date: May 5, 2017
• Grant date: Feb 16, 2021
• Expiry date: May 5, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to chiral compounds with two optically active phosphorus atoms, chiral transition metal catalysts which comprise these compounds as ligands, a process for preparing the P-chiral compounds and processes for asymmetric synthesis using the chiral transition metal catalysts. The present invention specifically relates to a process for preparing an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of an optically active transition metal catalyst according to the invention. Yet more specifically, the present invention relates to a process for the asymmetric hydrogenation of citral, and also a process for preparing optically active menthol.