Mu opioid receptor agonist analogs of the endomorphins
US10919939B2 · kind B2 · utility
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5References
22Claims
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Key dates
| Filing date | Apr 3, 2017 |
| Grant date | Feb 16, 2021 |
| Priority date | — |
| Expiry date | Apr 3, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain. Embodiments of the invention are directed to cyclic analogs of endomorphin. These peptide analogs exhibit decreased tolerance relative to morphine, increased solubility compared to similar tetrapeptide analogs, while maintaining favorable or improved therapeutic ratios of analgesia to side effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.