Chimeric antigen receptor
US10919951B2 · kind B2 · utility
1Cited by
1References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 17, 2018 |
| Grant date | Feb 16, 2021 |
| Priority date | — |
| Expiry date | Oct 17, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2239/46
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a chimeric antigen receptor (CAR) comprising; (i) a B cell maturation antigen (BCMA)-binding domain which comprises at least part of a proliferation-inducing ligand (APRIL); (ii) a spacer domain (iii) a transmembrane domain; and (iv) an intracellular T cell signaling domain. The invention also provides the use of such a T-cell expressing such a CAR in the treatment of plasma-cell mediated diseases, such as multiple myeloma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.